Ibogaine(18-MD) is a very unique 3-D molecule, almost in its own class of psychedelic drugs. It comes from a root bark found in Africa, and to this point, it has been impossible to synthesize. At low doses, the compound is used as a stimulant or aphrodisiac, but in high doses the molecule induces a sense of euphoria, sending the user into a dream-like state of closed-eye and open-eye visuals. Mood lifts, and spiritual and personal insight are both common effects from users, as well as heightened memory. The drug lasts for 24-36 hours when taken orally, with the first dream period lasting for 4-6 hours, beginning 1-3 hours after ingestion. The second period begins 4-10 hours after the dream state, and lasts 8-20 hours, where users tend to have a heightened sense of self reflection, with a high emotional response. The third period, mostly includes insomnia. Repeated anecdotal evidence has suggested that the drug has the potential to cure drug addiction, and removal of the sense of withdrawal, at least for 1-2 weeks. The psychological state of most opioid dependent users feel much better after the use of Ibogaine. For many addicts, repeated use of the drug in lower doses seems to help every few weeks, but the optimal use and dose has not been established.
Historically, it was prescribed as a stimulant, and for anti-depression. The 1960s was the first recording of ibogaine’s ability to cure addictions, and in 1986, the first patents for the use of Ibogaine were published for efficacy of correcting opioid dependence.
The main risk for Ibogaine is the increased risk of cardiac arrest. This danger is in large part, why the drug has not historically been funded for further research, but Mind Medicine is changing that, with a new approach to the drug, creating 18-MC.
In 1995, safety concerns of Ibogaine stopped FDA studies, but has continued to be used at anti-addiction clinics in Mexico and Canada as an uncontrolled substance. As with many drugs, there are many people who have experienced negative side effects, but if the heart problems associated with the drug can be solved, its medicinal potential is substantial.